Myomedins as immunogens elicit HIV-1 neutralizing antibodies
Thu May 27 12:48:23 CEST 2021
Event date:
Fri May 28 12:48:00 CEST 2021 - Thu May 27 12:48:23 CEST 2021 | Fri May 28 12:48:00 CEST 2021 - Thu May 27 12:48:23 CEST 2021
Fri May 28 12:48:00 CEST 2021 - Thu May 27 12:48:23 CEST 2021 | Fri May 28 12:48:00 CEST 2021 - Thu May 27 12:48:23 CEST 2021
Recently we have proposed “Non-cognate Ligand Strategy (NCLS) as a promising approach for the development of scaffold-derived epitope-mimicking proteins as vaccine immunogens. To support this approach, we developed a set of proteins called Myomedins that stimulated production of HIV-1 neutralizing antibodies in immunized mice. These variants mimic gp41/Env epitope recognized by broadly neutralizing antibody 10E8 and have potential to serve as HIV-1 vaccine components.
For details see:
https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1920251
