New opportunities for studying spatial proteomics

A prerequisite for cutting-edge competitive research is presented by high-end technology. In this context, Laboratory of molecular therapy (IBT CAS/BIOCEV) have established a new instrument from Akoya Biosciences, Phenocycler, that allows to study spatial proteomics in biological samples.

Normal and pathological tissue cross-sections can be assessed in one step for up to 60 proteins using antibodies on the level of individual cells. This makes it possible, for example, to study expression of proteins in cancer cells and subtypes of cells of the immune cells and other cells infiltrating the tumour stroma, and to specifically quantify this expression in individual cells. This is an example of one of a number of applications.