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Horizontal mitochondrial transfer (HMT) presents a phenomenon where mitochondria move between cells including mitochondrial DNA (mtDNA), in most cases with a functional impact for the cell that obtains mitochondria and, sometimes, also for the cell that loses these organelles. This phenomenon has been uncovered relatively recently, with first reports in the 90s of the last century.

Antibiotic resistance - some structural biology insights

Protein Production Facility – DNA & Proteins for Your Research

Horizontal Mitochondrial transfer: a new cancer hallmark with clinical relevance

Vestec, Czech Republic - The Instruct-ERIC research infrastructure gathered on November 21-22 at BIOCEV to discuss the present and future of structural biology. Hosted by the Institute of Biotechnology (IBT), the meeting brought together leading European researchers providing access to cutting-edge technologies and methods in the field to explore the future directions and accents in the European landscape of infrastructures.

Researchers from the Faculty of Science at Charles University, three institutes of the Czech Academy of Sciences (IMG, IBT and IOCB), BIOCEV and CEITEC have made a remarkable advancement in understanding how cells regulate their inner framework. In a study recently published in Nature Communications, the team has uncovered the precise molecular mechanisms behind the protein MICAL1, which plays a crucial role in maintaining cell shape and movement. ...

Vestec, Czech Republic — Last week, the Institute of Biotechnology hosted the MOSBRI conference at BIOCEV, where leading researchers, data repository experts, and biophysicsist convened to address critical challenges in the field: effective data management and accessibility. The two-day event, held on November 7th and 8th, fostered discussions on advancements in interoperability and integrative approaches to data sharing and analysis.

Teams of researchers from the Institute of Biotechnology led by prof. Jiri Neuzil and the Institute of Experimental Medicine led by dr. Pavel Vodicka and dr. Sona Vodenkova recently published a review paper in the highly acclaimed journal Trends in Cancer, focusing under the title of Mitochondrial DNAdamage, repair and replacement.

Introduction of novel phage endolysins as a tool for eradication of biofilm-associated multidrug-resistant Gram negative pathogens

A team of scientists from the Institute of Biotechnology of the Czech Academy of Sciences (IBT CAS) and the Institute of Experimental Medicine of the Czech Academy of Sciences (IEM CAS), supported by colleagues at the Institute for Clinical and Experimental Medicine (IKEM), has made significant strides in understanding how the brain recovers after a stroke. ...

In a recognition of computational biology's power, this year's Nobel Prize in Physics celebrates the breakthrough solution to one of science's most persistent challenges: the protein folding problem. This achievement, made possible through the innovative combination of bioinformatics and artificial intelligence, demonstrates how validated, machine-readable data drives modern scientific discovery.

On October 24 and 25, 2024, the First International Conference on Horizontal Mitochondrial Transfer and Dynamics (HMTD) took place at the BIOCEV center in Prague. The main organizer was Prof. Jiří Neužil, head of the Laboratory of Molecular Therapy at the Institute of Biotechnology.

One of the main challenges of contemporary medicine is posed by the resistance of pathogens to antibiotics. An important step in countering it has now been made by researchers from IOCB Prague, in collaboration with colleagues from the Institute of Microbiology and the Institute of Biotechnology of the Czech Academy of Sciences. ...

NMR contributions to understand the role of RNA conformational plasticity

From October 13 to 15, 2024, the picturesque Chateau Liblice hosted the 29th edition of the Symposium of Biology and Immunology of Reproduction (SBIR). This long-standing conference brought together 62 participants, primarily from the Czech Republic and Slovakia, to discuss the latest advancements in reproductive biology, assisted reproduction, and immunology.

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A meeting of students from prestigious scientific institutes was held at the Liblice Chateau. Representatives from the Institut Curie, Cordelier Research Institute, and the Biotechnology Institute participated in the event.

Researchers from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic, along with the 1st Faculty of Medicine of Charles University and the National Institute for Cancer Research at the BIOCEV center, have made a groundbreaking discovery regarding regenerative cells that could significantly enhance wound healing processes. Their findings suggest that wounds can heal without scarring, contingent upon the presence of Regeneration Initiation Cells (RICs).

A prerequisite for cutting-edge competitive research is presented by high-end technology. In this context, Laboratory of molecular therapy (IBT CAS/BIOCEV) have established a new instrument from Akoya Biosciences, Phenocycler, that allows to study spatial proteomics in biological samples.

Nucleid Acids Structural Bioinformatics

The Institute of Biotechnology of the Czech Academy of Sciences (BTÚ) has achieved significant success in the Ministry of Education, Youth and Sports' Operational Programme Jan Amos Komenský (OP JAK) – Intersectoral Cooperation.

International research team led by Libor Macurek (Institute of Molecular Genetics, Czech Academy of Sciences), Robert Grosse (Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg) and Zdenek Lansky (Institute of Biotechnology, Czech Academy of Sciences) identified a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division. ...

In EMBO’s 60th anniversary year, 100 new Members and 20 Associate Members join the community. One of them is Zdeněk Lánský, head of the Laboratory of Structural Proteins.

Basic overview and hands-on experience in methods of protein crystallization and diffraction.

Small angle X-ray scattering is a powerful method for in solution characterization of macromolecular structures. The course will provide practical experience with the data collection and processing.

Scientists from the Institute of Biotechnology have successfully developed novel small protein blockers of human interleukin-6 receptor alpha (IL-6Rα) and, in collaboration with researchers from other academic institutions, extensively functionally tested.

How understanding metabolism informs cancer progression

Structural basis of MICAL autoinhibition and activation

Microtubule doublet assembly in vitro and its regulation by PACRG and FAP20

IBT employees only

Identifying leukemic stem cells in single-cell data using ScarfWeb and Cellhub Uncovering the Hidden Insights: Empowering Researchers with Single-Cell Genomics Data Ecosystem

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Research team of the Laboratory of Ligand Engineering with its collaborators from Palacky University Olomouc (UPOL) has recently reported on engineering of small PD-1 binding proteins named Myomedins MBA that benefit diagnosis of non-small cell lung carcinoma (NSCLC) patients in vitro and monitoring PD-1 positive cell populations in vivo using positron emission tomography (PET/CT).

Adaptations to loss of pyrimidine de novo synthesis in lung cancer

3D spheroids of multipotent mesenchymal stromal cells: functional properties and strategies for biopreservation

Superspecialized mitochondria of Giardia intestinalis

Each year, the student organization ADIC (Association of PhD Students and Young Post-Docs of Institut Curie) collaborates with a top European institution for this retreat. This time around, they've chosen to partner with IBT and The Centre de Recherche des Cordeliers (CRC).

Mitochondria harbour two important pathways: the Krebs cycle and oxidative phosphorylation (OXPHOS). While Krebs cycle is a hub of catabolic and anabolic pathways essential for proper physiology and function of a cells, OXPHOS is the major source of cellular energy in the for of ATP. Thus, the two pathways are under strict control. They are connected with each other by mitochondrial respiratory complex II (CII), also referred to as succinate de-hydrogenase (SDH). ...

Unraveling the architecture of ASK1: insight into TRX1-mediated regulation

Engineering of antibody-based theranostic molecules targeted to prostate cancer

“SAXS and SONICC: Two techniques helping in Structural Biology”

The role of miRNAs in spinal cord injury: A novel therapeutic approach or diagnostic criterion?

No Swimming, No Life: New Insights into Sperm Immotility

Structural Bioinformatics of Nucleic Acids: The Sleeper Must Awaken

How to resolve fuzzy complex with protein engineering

This basic-level school is aimed at biologists, biophysicists, biochemists, structural biologists, etc., who want to learn a technique enabling high throughput screening for dynamic parameters of biochemical interactions on a single molecule level.

Horizontal mitochondrial transfer in the tumor microenvironment and the role of Miro1

Identification of novel pathways regulating transition between proliferation and quiescence of breast cancer cells

Mitochondrial iron chelation as an anticancer therapy: The role of the NDRG1 tumor suppressor

Cancer-associated fibroblasts and their role in cancer

When will RNA get its AlphaFold moment?

The President of the Czech Science Foundation (GACR) together with the Minister for Science, Research and Innovation awarded the five best scientific projects at the 20th anniversary ceremony of the Czech Science Foundation President's Awards yesterday (12 October 2023) at the Martinský Palace. The award recipients from all areas of basic research have contributed to a significant expansion of knowledge in the field and will lead to further applications.

Scientists from the Institute of Biotechnology (BTU) of the CAS at the Biotechnology and Biomedicine Centre of the Czech Academy of Sciences and Charles University (BIOCEV) and the Institute of Clinical and Experimental Medicine (IKEM) have elucidated the crucial role of the NEUROD1 protein in the development of severe diabetes. MODY6 diabetes is a subtype of diabetes caused by a mutation in the neurogenic differentiation factor 1 (NEUROD1) gene. ...

For the excellent results of the project "The role of NEUROD1 and ISL1 in the development of inner ear neurons" Gabriela Pavlínková received an honorary recognition from the President of the Grant Agency of the Czech Republic (GAČR) last week.

Cancer cells need an immense amount of building material to proliferate. When they run out, they are able to persuade healthy nearby cells to supply them. How they do so is the subject of research done by Kateřina Rohlenová from the Institute of Biotechnology of the CAS: “We already know quite well what happens on the inside of cancer cells. We now want to map what happens in their surroundings. ...

During his stay in the Czech Republic, Nobel Prize winner in Physiology and Medicine Professor Gregg L. Semenza visited IBT at the BIOCEV center. It was the first visit of a Nobel Prize winner in the history of the center and his lecture on "Hypoxia-inducible factors in Physiology and medicine" filled the conference hall to the last seat.

Centrum molekulární struktury spolu s odborníky z CCP4 pořádá praktický kurz o softwaru CCP4

The first IBT Student Day- an informal event to discuss science, encourage new connections and foster collaborations between the IBT labs

Reproduction in research and clinical practice

The application of label-free biophysical techniques, such as Isothermal Titration Calorimetry (ITC), Label-Free Microscale Thermophoresis (LF MST), and Differential Scanning Fluorimetry (DSF) for the characterization of protein interactions.

The Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) and four institutes of the Academy of Sciences of the Czech Republic have started a new collaboration on the education of doctoral students.